Chronic Respiratory Disease in Chickens

By Chicken Fans Editorial Team
Medically Reviewed by Dr. M. Amjad, DVM
University of Veterinary and Animal Sciences, Epidemiology and Public Health

Chronic Respiratory Disease is one of the most common bacterial infections threatening flocks worldwide. Once it enters the flock, it’s there to stay. Is it possible to keep it out and what to do when one of your chickens is infected?

Let’s find out.

What is Chronic Respiratory Disease in Chickens?

Chronic Respiratory Disease (CRD) or mycoplasmosis is a widespread bacterial respiratory disease caused by Mycoplasma gallisepticum (MG). Birds have watery eyes, nasal discharge, cough, and gurgling sounds. It’s a very common poultry disease that can be difficult to eradicate once it enters a flock.

The mycoplasma bacteria prefer chickens that are under stress. An infection can stay dormant in the chicken’s body, only to pop up suddenly when the chicken is under stress. Once the disease develops, it’s very contagious and has several ways of spreading through the flock.

Mycoplasmosis is one of the most common diseases seen at veterinarian offices. Roosters and young pullets usually suffer the most from an infection.

First Aid in Respiratory Issues in Chicken

  • VetRx Veterinary Aid: Place a few drops of warm VetRx, straight from the bottle, down the throat of the bird at night. Or dissolve VetRx in the drinking water (one drop for one cup).
  • EquiSilver Solution: Add the solution to the nebulizer. Gently hold the nebulizer mask to their head, covering the beak and nostrils completely. Allow nebulizer to cycle through entire process.
  • Equa Holistics Probiotics: Sprinkle 1 scoop per 30 chicks (from 0 to 4 weeks of age), per 20 young chickens (from 5 to 15 weeks of age), or per 10 adult chickens (over 16 weeks of age) on their food on a daily basis.

What to do if Chronic Respiratory Disease is Present in your Flock?

If you have reason to believe that one or more chickens in your flock may have CRD, or if you observe symptoms of the disease, it’s important to take prompt action.

Begin by administering “First Aid” treatment to provide immediate relief and supportive care for your birds. Next, implement quarantine measures and seek the assistance of a veterinarian for an accurate diagnosis.

First Aid for Chronic Respiratory Disease

Since the disease remains inactive in the flock indefinitely, no known cure or product can eliminate it completely. Nonetheless, various over-the-counter medications can alleviate symptoms and comfort your chickens.

Steps to take after suspecting Chronic Respiratory Disease in your Flock

  1. Isolate the infected chickens and place them in a comfortable location with easy access to water and food
  2. Limit stress for the birds 
  3. Seek the assistance of your veterinarian for the correct diagnosis and treatment
  4. Remove all chickens from the coop for disinfecting
  5. Clean and disinfect the chicken coop floors, roosts, walls, ceilings, and nest boxes.
  6. Allow at least 7 days for the coop to air out before returning your noninfected birds

Symptoms of Chronic Respiratory Disease

Please note that only a veterinarian can make a correct diagnosis. The most common way to diagnose is by using a real-time PCR test. But we’ll address common symptoms of CRD.

Chronic Respiratory Disease is an upper respiratory infection, and all symptoms are related to respiratory distress. At first, it can look like a mild eye infection. When the infection worsens, birds have difficulty breathing and nasal discharges.

symptoms of chronic respiratory disease in chickens: sneezing, nasal discharge, watery eyes, foamy eyes, bubbles, gurgling, coughing, yawning, head-shaking, difficulty breathing, loss of appetite, lower egg-production

Symptoms of Chronic Respiratory Disease are:

Mycoplasmosis oftentimes emerges as a complication with other infections and diseases. In those cases, many more symptoms can appear.

The severity of the symptoms varies with vaccination status, involved strains, immunity, and age. Symptoms are usually milder for older hens.

When the air sacs and lungs of the chicken become infected, the disease can be fatal.

Similar Diseases

Diagnosis can be difficult as the symptoms are very similar to other respiratory diseases, such as:

Transmission of Mycoplasma

Chronic Respiratory Disease is contagious and can be introduced into the flock via infected birds. These can be other chickens, but also turkeys or wild birds. The bacteria can also be brought in via clothes, shoes, equipment, or even our skin.

Once inside the flock, the bacteria spread via direct contact, contaminated food and water, and aerosols in the air. Unfortunately, the infectious agent also spreads through the eggs, making it challenging to eliminate the bacteria in an infected flock.

Transmission paths of mycoplasma: aerosols, contaminated food and water, direct contact and eggs

Spreading is usually very slow, and distribution through the air is probably not the primary propagation route.

Mycoplasmosis in chickens is not contagious to humans and poses no health risk. Some Mycoplasma species can affect humans, but these are different from the ones infecting our chickens.

Treatment of Chronic Respiratory Disease

Several antibiotics, like tetracyclines, can help in the fight against mycoplasmosis, but none of them will thoroughly remove the bacteria. Once a flock gets infected, the bacteria are there to stay. Antibiotics can only help recovery and decrease transmission to other chickens.

The disease stays dormant in the flock for a lifetime. Therefore, it requires treatment on a monthly basis to keep the disease suppressed. If you introduce new birds to the flock, they will probably get infected too.

Many flock owners choose to depopulate and replace the flock with new birds. Even when replacing all birds, it’s essential to disinfect the premises thoroughly to eradicate all the bacteria.

Can you treat Chronic Respiratory Disease Naturally?

Since Chronic Respiratory Disease stays in the flock for life, the birds must be treated continuously with medication. This chronic use of antibiotics has a substantial risk of bacteria becoming resistant to the antibiotics.

To tackle this, scientists are searching for alternative herbal medicines to replace antibiotics. In 2017, researchers discovered that extracts of the Meniran plant are highly effective against Mycoplasma gallisepticum.

Meniran herbs contain multiple bioactive compounds with antibacterial activity, such as terpenoids, alkaloids, flavonoids, saponins, and tannins. Later studies confirmed these results and reported that Meniran extract 65% supplementation had a significant effect on the chicken’s health.

While these results are promising, don’t expect the same substantial improvements from herbal remedies compared to antibiotics.

antibiotics for chickens

Impact of Chronic Respiratory Disease after recovery

Even after recovery, birds carry the bacteria latently in their body. These bacteria don’t cause any clinical symptoms, but they do impact the chicken’s body. The main side effect is a small but significant chronic decrease in egg production for egg-laying hens.

The same applies to chickens that are vaccinated with attenuated live vaccines, as we will discuss later.

Risk Factors

Many chickens are carriers of the bacteria but don’t show any symptoms until they become stressed. Stress can emerge in many forms.

Examples of risk factors that can trigger stress-induced mycoplasmosis include:

It’s not always obvious what the stressors are, and sometimes it doesn’t take much to get to the tip-over point. Even a sudden change in weather and climate can trigger enough stress for Mycoplasma to take over.

Prevention of Chronic Respiratory Disease

Prevention for Chronic Respiratory Disease consists of three main components:

  • reducing stress and avoiding stressful situations
  • preventing the bacteria from entering the flock
  • vaccination

Practically this means:

All these measures are critical when dealing with baby chicks. It’s a long list of criteria, but most of these measures should be part of your standard daily routines. It helps to add antibiotic supplements to the drinking water in stressful scenarios.

Now, there is something to be said about vaccination.

Vaccination for Mycoplasmosis

There are two types of vaccines available:

  • bacterins – vaccines based on killed and deactivated bacteria
  • living vaccines – vaccines based on weakened live bacteria of the F-strain, ts-11 strain, or 6/85 strains
vaccination of chickens


Bacterins are the safest because they are completely inactivated and can’t make chickens sick. But they aren’t commonly used as they come with a high cost. They are also less effective than live vaccines as they can only temporarily control infections and don’t have a substantial effect on protecting a chicken’s respiratory system in the long term (Kleven). Therefore, birds need to get repeated doses of the vaccines.

Live Vaccines

The live vaccines are much more effective, but they contain the actual bacteria. They are virulent and come with adverse side effects. Vaccinated flocks have a decreased egg production compared to entirely unvaccinated flocks. Scientists researched 132 commercial flocks and reported a difference of about eight eggs per year per layer hen. This difference is negligible for small backyard flocks but substantial for larger poultry farms.

The most significant disadvantage of live vaccines is that they make the birds sick. They carry the disease and will spread it to other birds. That’s a tremendous problem for chicken owners that also keep turkeys. In turkeys, the condition is much worse than in chickens and comes with severe symptoms. Especially the F-strain-based vaccines are very virulent.

Other vaccines have been developed based on the ts-11 and 6/85 strains to overcome the virulence of the F-strain vaccine. These vaccines are less pathogenic but tend to be less effective too. Some layer flocks that were vaccinated with ts-11 and 6/85 chains still had outbreaks and had to be re-vaccinated with the F-strain variants.

Future Vaccines

Currently, scientists are researching new ways to overcome the issues with the existing vaccines. These vaccines use modern techniques, such as the development of a recombinant adenovirus-based vaccine. These novel vaccines show promising results and chances are they will be more efficacious and less expensive than the current options.

Prevalence of Chronic Respiratory Disease

Some sources estimate that 65% of the world’s chicken flocks carry Mycoplasma bacteria. It’s a worldwide disease, but the prevalence varies per country.

prevalence of chronic respiratory disease in the world varies, as an example higher than 90 percent in ivory coast vs lower than 5 percent in belgium

For example, in Ivory Coast, the prevalence of Mycoplasma gallisepticum in 2021 surpassed the 90%-mark in eighty health-improved modern poultry farms. On the contrary, in Belgium, the prevalence of M. Gallisepticum in layers and broilers was lower than five percent. Researchers assume this is mainly because the eggs for breeding are under official surveillance in Belgium.

These are official numbers coming from commercial poultry farms. However, the disease occurs very commonly in far less regulated backyard chicken flocks.

Interaction with other Bacteria and Diseases

Chronic Respiratory Infection is caused by Mycoplasma gallisepticum and uncomplicated infections in chickens are generally relatively mild. Unfortunately, the bacteria usually join an army of other bacteria. Especially E. coli infections are typically coming along. An E. Coli infection results in severe inflammation of the chicken’s air sacs, heart, and liver.

Actually, Mycoplasma gallisepticum is only one type of Mycoplasma. There are several genera and only some of them will lead to Chronic Respiratory Disease. When a vet or lab technician tests for Chronic Respiratory Disease, they make a differential diagnosis to isolate the pathogenic mycoplasmas. That’s why they use a PCR test. It’s a molecular test that analyzes an upper respiratory swab looking for the genetic material of Mycoplasma gallisepticum.

Apart from E. Coli, other common concurrent secondary infections include Newcastle Disease, Avian Influenza, Infectious Bronchitis, and Infectious Laryngotracheitis.

Mycoplasma gallisepticum

Mycoplasma is a remarkable genus of tiny bacteria that lack a cell wall. That’s why they are exceptionally resistant to several antibiotics. Most antibiotics kill bacteria by destroying their cell wall.

mycoplasma gallisepticum

Hundreds of varieties exist that cause respiratory diseases in animals, insects, and humans. Some types can even affect plants. They all come in various shapes and with a size of around 100 nanometers, they are among the smallest organisms yet discovered.

It is mainly Mycoplasma gallisepticum that is causing Chronic Respiratory Disease in chickens, turkeys, pigeons, and other birds. However, chickens can also suffer from a concurrent infection with Mycoplasma synoviae. These bacteria also affect the bones and joints of a chicken, on top of the respiratory system.


Chronic Respiratory Disease, or mycoplasmosis, is a widespread stress-induced bacterial disease that affects the upper respiratory system of chickens and other birds. It’s a very persistent disease, and once it enters the flock, it’s there to stay. Although it can be treated with antibiotics, the bacteria will survive latently in the chicken’s body.

Once your flock is infected, you have to choose to depopulate or carry on with the flock in the knowledge that the infection is present. No other chickens can be introduced or removed from the flock.

There are multiple vaccines available. Some vaccines are based on deactivated bacteria and are very safe to use. However, they are less effective, costly, and must be administered regularly. Other vaccines are based on live bacteria but will infect your chickens. This is especially problematic if you have turkeys, as the disease is much more severe for turkeys.

Chickens that survive the disease won’t show clinical signs of illness but can show some side effects, like decreased egg production. This also applies to chickens that are vaccinated with live vaccines.

Dr. M. Amjad, DVM
University of Veterinary and Animal Sciences, Epidemiology and Public Health

Dr. M. Amjad is a licensed veterinarian with vast experience in diseases, management, and treatment of chickens from working as an assistant manager at poultry farms and feed mills. He has published work on risk factors of antimicrobial resistance of campylobacter species found in poultry meat.

Chicken Fans Editorial Team

The editorial team consists of 3rd generation chicken owners Kat, journalist, editor-in-chief, and Nick, working with illustrators and specialists in the field.